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For example, the energy restriction assists the NAD+-induced deacetylation of downstream p53 and NF-B via Sirt2, leads to prolonged life span and improved anti-aging effect cardiomyocytes [49, 115]

Through systematic in vitro , in vivo , and clinical investigations that document both efficacy and normal tissue responses, EMF-based therapies may be refined to maximize anti-tumor activity while minimizing unintended toxicity

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