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In line with this observation, the 37% of lung adenocarcinoma cases that present elevated expression of ser/gly synthesis enzyme genes displayed worse overall survival rates as compared to the 63% of lung adenocarcinoma cases with low expression of ser/gly synthesis enzymes genes ( n = 187 and n = 320, respectively, p = 0.004 , q = 0.0177) (Fig

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Divided into three groups, participants received oral supplementation of GSH (250 mg/d), GSSG (250 mg/d), or a placebo for 12 weeks

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Mechanistically, microglia with elevated G6PD activity produce excess NADPH, which provides abundant substrate for overactivated NOX2