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3.3 Pathological markers: axonal degeneration, demyelination, and microvascular damage Current studies consistently indicate that the core pathological manifestations of DPN include: axonal degeneration (Galiero et al., 2023), Schwann cell-mediated demyelination (Chong and Souayah, 2025), and neurovascular microcirculation dysfunction (Zhu et al., 2024), which together constitute the major forms of damage

Biomarkers are important in confirming AD pathology and guiding targeted therapies 6

Lachner, M., OCarroll, D., Rea, S., Mechtler, K

(2022) 7:e52936

The most commonly reported indications are nausea and vomiting, urinary tract infections, preparation for and/or facilitation of labor, common cold or flu, gastrointestinal problems (e.g., constipation, flatulence), pain conditions, improvement of fetal outcomes, prevention of miscarriage, relief of anxiety, treatment and/or prevention of anemia, and treatment of edema (Kennedy et al., 2013

In addition, experts advise keeping a food diary for a short period of time to identify potential food triggers that may make fibro symptoms worse, including dairy, MSG, caffeine, or artificial sweeteners