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Based on their activation states, microglia are typically classified into two types: classical pro-inflammatory activation (M1) and alternative anti-inflammatory activation (M2) ( Moreover, microglia exhibit significant sex dimorphism in their functions, which may contribute to the sex differences observed in morphine tolerance

10.1016/j.jaad.2024.07.1522

Chembiochem 8 , 341352 (2007)

M.PrubetaB

3e), likely reflecting the cellular heterogeneity in terms of both fluorescence output and biotic damage, which is particularly critical in this region close to the infection source