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These results show that senescence of lung epithelial cells is likely related to the development of COPD/emphysema and that, during the induction of COPD/emphysema, smoking elevates senescence-related indicators and miR-125a-5p levels in lung tissue

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The transcription factor Forkhead box J1 ( FOXJ1 ), required for multiciliated cell differentiation, along with transcriptional coactivators regulatory factor X ( RFX ) 2 and RFX3 [16] were also overrepresented in this analysis

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