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Interferon (IFN) is a signal protein produced by infected or cancerous cells to bolster the immune response of neighboring cells (Marieb 2010)

38 Mitochondrial disorders such as Leigh syndrome involve impaired energy production due to dysfunctional mitochondria, which disrupts the energy supply needed by neurons and results in neurodegeneration

This discrepancy between mechanistic rationale and clinical outcomes represents a critical challenge in rheumatology, forcing a re-evaluation of how well our preclinical models truly capture the drivers of established axial disease

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doi: 10.1111/jcmm.14212 91 LeiSPengFLiMLDuanWBPengCQWuSJ