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Protein carbonyls, arising from oxidative cleavage, deamination, and Michael addition, along with advanced glycation end products (AGEs) like carboxymethyl lysine (CML), are among these markers

This neuroinflammatory cascade explains why the joint and muscle pain in ME/CFS and Long COVID often mimics fibromyalgia, presenting as widespread, migrating, and highly sensitive to even minor physical exertiona hallmark of post-exertional malaise (PEM)

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Jaramillo MC, Zhang DD

Milk Thistle also aids in improving conditions like jaundice, hepatitis, and certain cancers [13]

Data was shown as the percentage of fold induction of the test compound against the vehicle control group

doi:10.1515/acph-2017-0010 Al-Rasheed NM, Fadda LM, Attia HA, et al