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Some apparent improvements were weak or affected by inadequate control groups

However, the pharmacokinetics of cagrilintide are dose-proportional and linear, with exposure determined primarily by apparent clearance (CL/F) at any administered dose, and AUC defined as dose/(CL/F), thus allowing direct comparison across different dosing regimens

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Cagrilintide's half-life of approximately seven days allows for flexible dosing windows (administration can be delayed by 12 days without loss of efficacy), but missed doses beyond five days require restarting the titration schedule to avoid rebound nausea