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mtDNA is essential for maintaining mitochondrial function, but it is more susceptible to being damaged by ROS than nuclear DNA since it is closer to the mitochondrial ROS production site, after which mitochondrial genome stability is influenced and diseases occur

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Cell membranes: All animal cells are surrounded by a lipid bi-layer that comprises phospholipids (a phosphate group attached to a saturated or unsaturated fatty acid), membrane proteins and cholesterol