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Consequently, Tanzanian mangrove endophytic fungi may represent a promising reservoir for natural antioxidant discovery, highlighting the biotechnological value of conserving these unique ecosystems

Consistent with the role as a second hit, MAPK are known to be activated by oxidative stress and have been involved in APAP hepatotoxicity

35,36 For instance, EGF through the cognate receptor induced the expression of the caspase 1 enzyme and p21 WAF1/CIP1 toward apoptosis and growth inhibition