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Apart from acetate, an important source of cytosolic acetyl-CoA is by cleavage of citrate that originated from mitochondria, catalyzed by ATP-citrate lyase 264,280,281

The systemic impact of age-related AT dysfunction extends beyond local effects, contributing to widespread metabolic dysfunction and chronic low-grade inflammation (401)

2010 Jun;64(7):968-83

Additionally, in vitro models derived from different species, such as rats and rabbits, complicate the extrapolation of results to human clinical conditions due to interspecies differences

10.1093/nar/gkab1028 47 GilmourN.KernP