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Acknowledgements The study was supported by grants from the Natural Science Foundation of Heilongjiang Province of China (PL2024H080 to HBL and ZD2023H005 to JWT), the Open competition mechanism to select the best candidates for key research projects of Ningxia Medical University (XJKF230107 and XJKF240307 to HBL), the postdoctoral scientific research developmental fund of Heilongjiang Province (LBH-Q16146 to HBL), Heilongjiang provincial research institute scientific research expenses project (CZKYF2024-1-B038 to HBL)

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