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In LC, Plin2 drives NSCLC proliferation by inhibiting autophagy via AKT/mTOR activation (41), whereas circFAM190B propels tumor progression by suppressing autophagy through the SFN/mTOR/ULK1 axis (42)

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Studying the effects of JS-K on AR- and WNT-signalling in the AR-positive PCa cell lines 22Rv1 and LNCaP we were able to demonstrate that only a 100-fold lower concentration of the GST-activated JS-K are necessary to reach comparable biological effects in PCa cells than the commonly used DETA/NO that spontaneously generates NO in physiological fluids

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