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10.1016/j.ejro.2023.100495 Eur

They are polarized tissues due to the differential expression of ion channels, pumps and transporters in the apical and the basolateral sides: (a) epithelial sodium channels (ENaC), Ca 2+ activated chloride channels and the cystic fibrosis transmembrane conductance regulator (CFTR) are present in the apical plasma membrane and (b) the Na + -K + -ATPase ion pump and the Na + -K + -2Cl cotransporter in the basolateral side

2007, pp

[29] showed that patients with bilateral involvement and a long history of pain and limited function had significantly poorer results

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