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Acknowledgements The authors thank all members of the laboratory for their assistance with animal care and experimental procedures

The needle length helps direct water down the vial wall rather than directly onto the powder

Apoptosis: controlled demolition at the cellular level

The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system

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Although numerous studies have highlighted the critical role of RCD mechanisms in NAFLD/NASH and related HCC, significant challenges remain in developing effective targeted therapies and translating them into clinical applications