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Of particular concern is the recent rise in early-onset colorectal cancer (EOCRC)

A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis

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Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al

J Affect Disord 76:5568

Nevertheless, the combinatorial treatment with tamoxifen and antioxidants could promote anti-cancer efficacy of tamoxifen as was demonstrated in the model of DMBA-induced mammary carcinogenesis in SpragueDawley rats in which an administration of tamoxifen in combination with riboflavin, niacin, and coenzyme Q10 restored lipid peroxide level and the activity of anti-oxidants accompanied by enhanced antitumor activity [110]