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had employed MCF-7R, a multidrug-resistant breast cancer cell line, to testify to the chemosensitizing properties of curcumin

Furthermore, p-JNK leads to the activation of Bax and translocation to mitochondria to trigger the mitochondrial permeability transition (MPT) pore formation, along with collapsed ATP depletion and membrane potential, eventually causing DNA fragmentation and necrosis ( via upregulation of Gadd45

Furthermore, we found that HFD consumption also led to decreased hepatic expression of glutaredoxin, a key enzyme for de-glutathionylation

Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes

Studies of spatial learning and memory on animals Many researchers use a water maze in their studies of spatial learning and memory in reaction to genetic modification or treatment