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Mechanistically, at very low, non-toxic concentrations, the peptide stimulates collagen, glycosaminoglycans, and proteoglycans such as decorin, while modulating the matrix metalloproteinases involved in extracellular matrix remodeling during healing

The peptide was first described by Professor Predrag Sikiri's group at the University of Zagreb in the early 1990s.nnWhat stands out about BPC-157 is its stability in acidic conditions

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FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation