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Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity

The inner NP is a gel-like tissue that is rich in randomly arranged collagen, such as aggrecan (Acan), and radially arranged elastin fibers, which provide a stable structural basis for bearing the spinal stress load and protecting nucleus pulposus cells (NPCs) [4,5,6]

In fact, we have detected that MEN produces mitochondrial dysfunction caused by GSH depletion, which alters the mitochondrial permeability resulting in the release of cytochrome c and DNA fragmentation, biomarkers of apoptosis through the intrinsic pathway

In other contexts, cells may increase glutathione as an adaptive response

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