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By designing systems with features such as release only under certain conditions means that greater control and more specific targeting can be achieved

1.5 Activation of redox signaling pathways: Oxidative stress can activate intracellular redox signaling pathways, including the nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway (41) and the NF-B pathway

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doi: 10.1111/pme.12413

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Some metals generate free radicals, leading to damage of vital cellular proteins, membranes, and organelles, potentially causing apoptosis ( Figure 1 MTs are a group of low molecular mass (7 kDa), cysteine-rich and evolutionarily conserved metal-binding proteins (Lynes et al., 2014)