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The role of Ketone bodies in metabolism and cancer treatment Ketone bodies may play a role through various metabolic pathways such as fatty acid -oxidation (FAO), de novo lipogenesis, sterol synthesis, the tricarboxylic acid (TCA) cycle, and gluconeogenesis [36, 37]

High concentrations of ROS in the ER lumen may also subsequently activate the ER calcium release channel type 1 inositol 1,4,5-trisphosphate receptor (IP3R1), leading to the leakage of calcium from the ER lumen into the cytoplasm