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In fact, estimation of the frequency of DNA lesions by Poisson distribution indicated that the combination of cisplatin and BSO induced more DNA damage than either drug alone (Figure 3f)

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doi: 10.1002/(sici)1097-4644(20000501)77:2 3.0.co;2-q 115 AmicarelliFColafarinaSCattaniFCiminiADi IlioCCeruMPet al

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Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N (2017) Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

4.2 Cytotoxicity As shown in Table 2, studies in the literature in the last two decades have found that compounds extracted from coral have good cytotoxicity, particularly diterpenes, sesquiterpenes, sterols, and a small number of alkaloids, prostaglandins, and esters as active substances that also have some biological activity