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SD-436 has no significant inhibition of the human ether-a-go-go-related gene potassium channels (hERG inhibition: 1.3% for 3M and 1.1% for 30 M) [1]

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Ideal alternatives would incorporate mechanisms of action that lower the risk of resistance

Currently, the approved HDACi in clinical practice has limited application possibly due to the pan-HDAC inhibition profile

In Stargardt disease, FLIO shows potential in monitoring disease progression and may eventually track treatment responses

(Campo et al