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The technique is especially appropriate for testing the whole taste sensory chains integrity including ionotropic transduction mechanisms, but excluding metabotropic transduction mechanisms because sweet bitter or umami taste transduction mechanisms rely on second messenger systems and are not activated by EGM stimulation (ionic stimuli) [43]

2023 Valavanidis A, Vlachogianni T, Fiotakis K (2009) Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles

#150 Effects of tobacco smoke on the respiratory system Tobacco smoke contains irritants and carcinogens

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