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However, for GSH, there was no significant difference between patients with LDH-induced radicular pain and patients with no-leg pain (Figure 2E)

Four types of ferroptosis inhibitors have been identified: GPX4 specifically catalyzes the loss of lipid peroxide oxidation activity in a GSH-dependent manner, FSP1 converts ubiquitin ketone on cell membranes to reduced ubiquitin, which can inhibit peroxidation and prevent iron droopy, GCH1/BH4 pathway is an endogenous antioxidant pathway, GCH1 protects cells from ferroptosis mainly through the antioxidant effect of BH4, and DHODH protects cells from ferroptosis in mitochondria by regulating the production of dihydrobisquinone in the inner mitochondrial membrane (Wang D

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[PubMed: 6140651] 49

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Conclusion: This study suggests those with TIA, compared to healthy controls, have greater p-tau and lower beta-amyloid suggesting an early AD type biomarker profile which may in part explain the increased risk of dementia post-TIA