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[DOI] [PubMed] [Google Scholar] 85.Therrell BL, Jr, Lloyd-Puryear MA, Camp KM, Mann MY

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This dysfunction leads to the loss of metabolic support (e.g., GLT1 downregulation) and the secretion of pro-inflammatory cytokines such as IL-1, TNF, and IL-6

In contrast to the animal models of the absence of GHR signaling, humans with GHR deficiency do not live longer