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9 Intramuscular Dosing Though studies have evaluated NADH IM for some conditions, very limited data exists on NAD+ for intramuscular use

Pharmacokinetics: Data indicate a linear pharmacokinetic profile with a short half-life ( 1000mcg/day) have been anecdotally associated with increased chances of headaches, fatigue, or water retention, and may lead to diminishing returns, suggesting a bell-shaped dose-response curve

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VO2 max and recovery improvements lead the timeline

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The skin's aging process leads to lower SIRT1 and SIRT6 levels, which directly links to reduced NAD+ availability