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the method comprises converting the compound of formula (XX) to an amino acid- or peptide conjugate of the formula (I) or a pharmaceutically acceptable salt or solvate thereof of the present invention by one or more additional synthetic steps: the method comprises converting the compound of formula (XX) to an amino acid- or peptide conjugate of the formula (IA) or a pharmaceutically acceptable salt or solvate thereof of the present invention by one or more synthetic steps: the one or more synthetic steps comprises removing the acetal in the compound of formula (XX) to provide a compound of the formula (XXIII-1): the method comprises removing the acetal in the compound of formula (XX) to provide a compound of the formula (XXIII-2) or (XXIII-3): the one or more synthetic steps comprise converting the hydroxyl group bound to the carbon to which R1 and R2 are attached in the compound of formula (XXIII-1) to L1-Z1-, and/or converting the hydroxyl group bound to the carbon to which Rx and Ry are attached to L2-Z2

PMID: 34685781

Supplementation Guidance While some individuals may benefit from supplements like methylated folate or B vitamins, others may not require additional supplementation

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Also, due to the lack of research on lipotropic injections, few dosages are available for reference

It can be idiopathic or result from an underlying condition