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10.1016/j.it.2010.03.001 12

If youre not supplying enough oxygen to your macular, because this is an area where the Achilles heel is metabolism

Here we show that SIRT3, a mitochondrial deacetylase highly expressed in HSCs but reduced during aging, suppresses the HSC response to aging that drives maladaptive trained immunity, chronic inflammation and tissue functional decline in mice