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In summary, the primary tumors release TDSFs, EVs, or directly carry stromal components to establish LPMN that are conducive to tumor metastasis

Gene ontology (GO) classification analysis revealed that differentially expressed genes were predominantly associated with immune system processes, responses to stimuli, and metabolic regulation at the biological process level, while intracellular and protein-containing complexes were enriched at the cellular component level, and binding- and catalytic-related functions were dominant at the molecular function level (Fig

proposed that the aggregates dynamics, maintained by electrostatic interactions, allow for reorganization and exposure of the aggregants (peptide) to the surrounding solute (protease)