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Other possible causes include: Uterine fibroids Perimenopause Ovulation spotting Stress or major lifestyle changes Injury or irritation from tampons, intercourse, or medical devices While occasional spotting may be harmless, persistent or unexplained bleeding should be evaluated by a healthcare professional

10.1158/1535-7163.MCT-07-2400 274 YuJ.PengY.WuL.-C.XieZ.DengY.HughesT.et al (2013)

Future perspectives of oxytosis/ferroptosis research in neurodegeneration diseases

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This mechanism involves the miR-3173-5p secreted by CAF exosomes, which specifically targets ACSL4

In some patients it gives a clue to the diagnosis of systemic disorders