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& Bernstein, B

( B ) Schematic of renal carnitine synthesis pathway where BBOX1 (surrounded with red) is the rate limiting enzyme

( Reference Martinov, Vitvitsky and Mosharov 39 ) , in a mathematical modelling study of SAM metabolism in the liver, stated that when SAM levels are low, priority for this substrate goes to transmethylation reactions, promoting reduction of the trans-sulfuration pathway