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J Mater Sci Technol

In other words, nature is continually tinkering with these independent folding units: a domain from archaea may not have the same sophisticated set of switches as the homologous domain from a mammalian protein

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Conclusions Main conclusions NTFs exhibit potential to modulate mitochondrial function through multi-targeted regulatory effects, forming an endogenous protective pathway that may mitigate dopaminergic neuron degeneration in PD

TRPA1 and TRPM8, but also the heat-sensitive TRPV1 and more recently, TRPV4, have also been found to be involved in paclitaxel-, vincristine- and thalidomide-induced neuropathy, where both increased channel expression and analgesic effects from antagonists were reported (Materazzi et al., 2012