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Moreover, healthy RPE cells have an enriched mitochondrial population and predominantly rely on mitochondrial metabolism (-oxidation, oxidative phosphorylation, and TCA cycle) to produce adenosine triphosphate (ATP) 10

We show that metabolic rewiring of these pathways by vitamin B12 reduces cholinergic transmission by limiting the availability of free choline required by neurons to synthesize acetylcholine

L-Arginine is an amino acid that serves as a precursor for the synthesis of nitric oxide, a potent vasodilator that plays a crucial role in maintaining vascular health

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Links between gut dysbiosis and neurotransmitter disturbance in chronic restraint stress-induced depressive behaviours: the role of inflammation

Nat Immunol (2021) 22:112739