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So, where do researchers go

When activated during pathogen infection or tumor development, macrophages secrete a variety of signaling proteins, including cytokines, into the extracellular space through both conventional and unconventional pathways 5,6

doi: 10.1093/rheumatology/ket178 170 ZhuMYuanKLuQZhuQZhangSLiXet al

PAPS provides sulfur for the synthesis or modification of several secondary metabolites including glucosinolates, peptides or hormones in reactions involving sulfotransferases (SOT)