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BiP/Grp78 expression levels are increased in the hippocampus and temporal cortex of AD, and several studies have reported the increased presence of phosphorylated PERK, IRE1, and eIF2 in AD neurons (82, 336, 337)

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Schiller CM, Fowler BA, Woods JS

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Variations in the administered dose can profoundly influence not only the magnitude of observed effects but also the potential for toxicity or subtherapeutic responses, thereby complicating cross-study comparisons