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Current treatment strategies primarily focus on symptom relief, with first-line drugs such as pregabalin and duloxetine partially reducing pain scores but failing to reverse the continuous reduction of epidermal nerve fiber density or repair demyelination, thus not achieving the goal of disease-modifying therapy (Tesfaye et al., 2022)

Keywords Opioid Narcotics (Morphine, Heroin, Fentanyl & Others) Sources: Prescription analgesics Illegal narcotics / drugs of abuse Mechanism of Action: opioid receptor agonist Symptoms: Clinical triad of: CNS depression Respiratory depression Pinpoint pupils (miosis) Meperidine & propoxyphene sometimes are associated with mydriasis or midpoint pupils (due to anticholinergic effects) Euphoria is frequently seen Hypotension & hypothermia the leading cause of morbidity and mortality from pure opioid overdoses is Death :

The global methylation status showed significantly increased 5-mC levels (Fig

Here, we determined the crystal structures of the GS from H

They work faster than creams and serums, which often need months to deliver minimal change on deep discoloration

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