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Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)-based editing have enabled targeted correction of nonsense mutations [184, 185]

For medium composition optimization, molasses (Konem Bio Co., Republic of Korea) and CSL (Shanghai Aladdin Bio-Chem Technology Co., China) were used as carbon and nitrogen sources

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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model