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Despite growing interest in organoids and 3D culture systems for modeling reproductive biology, research on EVs secreted specifically by reproductive organoids remains limited

In hAD-MSCS, chromatin immunoprecipitation (ChIP) analysis revealed Argonaute 2 directly regulated OCT4, which targeted Methyl-CpG Binding Domain Protein 6 (MBD6) to regulate genes associated with stemness-associated genes and self-renewal activity of MSCs [24] (Fig