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, ( 3 x 1) TFA(95% v/v), TIPS(2.5% v/v) (2.5% v/v)

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2024;16(3): e55378

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Unlike other isoforms, the expression of HO-1 is induced in conditions of oxidative stress, and is expressed in many tissues, including the kidneys.74 The renal expression of HO-1 is increased in experimental models of haemoglobinuria and rhabdomyolysis, as well as in patients with intravascular haemolysis.66,75,76 The deficiency of this enzyme in patients with intravascular haemolysis increases tubular and glomerular damage.77 Similarly, animals used in gene knockout studies for HO-1 have shown greater sensitivity to rhabdomyolysis, higher levels of creatinine and higher mortality rates.78 Transferrin Transferrin (Tf) is a glycoprotein that is mainly secreted by the liver, and which binds to free iron to mitigate its adverse effects.79 Depending on the iron concentration, the tubule cells express the Tf receptor (TfR1), which plays an essential role in the metabolism of this molecule in the kidneys.80 Its expression is regulated by the iron-regulatory proteins 1 and 2, which are highly expressed in the proximal tubules and which act as sensors of iron levels.8183 Under normal conditions, approximately 30% of the Tf iron-binding sites are saturated