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5.3 Micronutrient antioxidants used in IBD therapy Micronutrient antioxidants in IBD therapy include vitamins E and C, reduced glutathione, and selenium, as shown in Table 3

Glutathione acts to neutralize a toxic metabolic byproduct: Methylglyoxal Glutathione is involved in the protein disulfide bond rearrangement that is necessary for the synthesis of one third of the bodys proteins It protects the body from the oxidative damage caused by glutathione peroxidase by acting as a helper molecule for certain enzymes The liver uses Glutathione to help detoxify fats before the gallbladder emits bile, supporting healthy digestion Glutathione may also be crucial in the removal and detoxification of carcinogens, and according to recent studies17 alterations in this metabolic pathway, can influence cell survival profoundly

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Although the exact antibacterial processes of Ashwagandha are not entirely understood, several studies have shown that the presence of active molecules such withanolides and withanosides may be responsible for the antimicrobial action [90]

Cystic degeneration (spongiosis hepatis) and angiectasis (peliosis hepatis) may occur within foci of altered cells