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The resulting strain W303-1b/gsh1/F (F pathway) together with W303-1b/G (G pathway) and W303-1b/gsh1/pro1 (P pathway) represent different pathway strains (Table 2)

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Biochemistry and physiology of brain ammonia

Taken together, these findings indicate that hepatic GSH depletion confers substantial protection against the development and progression of HFD-induced MASLD/MASH, with improved insulin sensitivity