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The deletion of focal adhesion kinase (FAK) in CAFs leads to increased activation of cytokine signaling pathways and the upregulation of the expression of C-C chemokine ligand (CCL)6, CCL11, CCL12 and pentraxin-3, which increase the activity of glycolysis processes in breast and pancreatic cancer cells [331]

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Although the therapeutic advantages of EVs are evident, there are still shortcomings in practical application, such as low therapeutic efficiency and rapid degradation rates (Sterzenbach et al., 2017

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Well, your mitochondria, you don't really do that for the most part