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Evidence is mixed and inconsistent

118 employed chondroitin sulfate-soluble undenatured type II collagen complex (CS-SC II) compared to soluble type II collagen (SC II) in a rat OA model to investigate its gastrointestinal digestive characteristics and therapeutic effects

Excessive use can cause intestinal growth (distended stomach)

Markers frequently observed include: Neutrophil extracellular traps (NET) (also seen in Babesiosis) Increased D-dimer in subsets Increased fibrin production The thin layer lining blood vessels, the endothelium, appears to remain inflamed long after acute infection resolves