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Therefore, conclusions derived from these models should be interpreted with caution and validated in additional human systems

127 SIRT1 reduces H3K18 lactylation via delactylation and inhibits the H19/glycolysis/H3K18la positive feedback loop, playing an antitumor role in gastric cancer

HIF-1 is the key transcriptional factor that masterfully regulates endothelial cell biology and angiogenesis, particularly under hypoxic and oxidative stress conditions, by upregulating pro-angiogenic factors, such as VEGF 33