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Subsequently, patients transition to monthly injections of cyanocobalamin or injections every two to three months for hydroxocobalamin

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This aberrant SNO can lead to conformational changes and misfolding of the proteins that affect their functions [167]

1,21 Although it is generally accepted that patients receiving ICIs and combination ICIs may experience irAEs affecting multiple organ sites, the exact incidence of concurrent or sequential irAEs in the same patient has not been reported in the kidney cancer population

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