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In general, melanoma in your nail has a poorer outlook than melanoma on your skin

These protective effects are partly mediated by metabolic reprogramming, characterized by sustained enhanced glycolysis, mitochondrial oxygen depletion (236, 237), and mTOR activation (235)

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The COX is associated with oxidative phosphorylation in mitochondria, and its function is mainly mediated by five proteins: COX17, synthesis of cytochrome C oxidase 1 (SCO1), SCO2, cytochrome c oxidase assembly factor 6 (COA6) and COX11, each of which is essential

Oren et al., 2021

Protective effect of compound tongluo decoction on brain vascular endothelial cells after ischemia-reperfusion by inhibition of ferroptosis through regulating Nrf2/ARE/SLC7A11 signaling pathway