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Mol Med 22:694704 Sitkovsky M, Ohta A (2013) Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer

When a compound is already producing 50 pounds of weight loss, adding a second compound that might produce an additional 4 to 5 pounds over a similar period starts to look like complexity for minimal gain

The clinical evidence gap between these two compounds is enormous