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Patients typically take methotrexate once weekly (orally or by subcutaneous injection), alongside folic acid supplementation to minimise side effects

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If you are designing a controlled experiment, the cleaner design is usually two separate vials with matched-volume vehicle controls

For retatrutide, supplementation must be handled separately since no commercially compounded formulations exist

Studies have shown this does not work, but I have had patients report that it helps their lip dryness

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