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Tissue Regeneration: Activates progenitor cells, reduces apoptosis, and regulates actin polymerization (PubMed 22074294)

This work has also been supported by the Ministero dellUniversit e della Ricerca (MUR) through the PRIN project REPLAY grant number 2020SBNHLH_003

Andersson S, Berman DM, Jenkins EP, Russell DW

Compared with control mice, in mice deficient in the ASK1 gene, prolonged exposure to Ang II initiates a reduction in cardiomyocyte apoptosis, decreased hypertrophy, attenuated upregulation of hypertrophy-related mRNAs, and diminished pathological changes such as interstitial fibrosis and coronary remodeling [247, 248]

Generally, drops of more than 20 mmHg systolic or 10 mmHg diastolic warrant attention, particularly if accompanied by symptoms like dizziness or fatigue